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Electric Field Assisted Surface Plasmon-Coupled Directional Emission: An Active Strategy on Enhancing Sensitivity for DNA Sensing and Efficient Discrimination of Single Base Mutation

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Electric Field Assisted Surface Plasmon-Coupled Directional Emission An Active Strategy on Enhancing Sensitivity for DNA Sensing an.htm (392bytes)
Date
2011-01-25
Author
Cao, Shuo-Hui
Xie, Tang-Tang
Cai, Wei-Peng
Liu, Qian
Li, Yao-Qun
李耀群
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  • 化学化工-已发表论文 [14469]
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Abstract
We have demonstrated the proof-of-principle of electric field assisted surface plasmon-coupled directional emission (E-SPCDE). The combination of SPCDE and electric field control produced a significant synergistic effect to amplify the right signal and suppress the wrong signal intelligently in an active strategy. A novel hairpin structured DNA biosensor based on the quenching and enhancing of fluorescence in SPCDE has been designed. With modulation of the fluorescence coupling efficiency, a high discrimination ratio up to more than 20-fold has been achieved by enhancing the signal of match and suppressing that of mismatch. E-SPCDE has shown a successful application in DNA sensing, eliminating false positives and false negatives in the detection. E-SPCDE should provide an opportunity to create a new generation of miniaturized high-performance sensing platforms especially in chip-based microarrays and to make the manipulation of the nanometer-scale processes more accessible and detectable.
Citation
J. Am. Chem. Soc., 2011, 133 (6): 1787–1789
URI
http://dx.doi.org/doi:10.1021/ja107964s
WOS:000287831800049
https://dspace.xmu.edu.cn/handle/2288/11773

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