Show simple item record

dc.contributor.authorGao, Xiang
dc.contributor.authorZhu, Gangtian
dc.contributor.authorZeng, Zhiping
dc.contributor.authorChen, Weizhu(State Ocean Adm, Inst Oceanog 3)
dc.contributor.authorLin, Zhiwei
dc.contributor.authorLiu, Yan
dc.contributor.authorXu, Pengxiang
dc.contributor.authorZhao, Yufen
dc.contributor.author赵玉芬
dc.date.accessioned2012-03-11T02:47:44Z
dc.date.available2012-03-11T02:47:44Z
dc.date.issued2011-03-29
dc.identifier.citationRAPID COMMUNICATIONS IN MASS SPECTROMETRY,2011,25(8):1061-1069zh_CN
dc.identifier.issn0951-4198
dc.identifier.urihttp://dx.doi.org/doi:10.1002/rcm.4955
dc.identifier.uriWOS:000289264700008
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11693
dc.description.abstractThe mass spectral behavior of amino acid methyl ester phosphoramidate derivatives have been investigated using electrospray ionization multistage mass spectrometry (ESI-MSn) and moderate theoretical calculations at the B3LYP/6-31G(d) level. A novel methyl group migration to the phosphoryl group with the formation of the intermediate cyclic aminoacylphosphoramidate was found. The proposed structures of the rearrangement ions were confirmed by high-resolution tandem mass spectrometry. A possible mechanism involving the pentacoordinate phosphoric-carboxylic phosphate anhydride was proposed, in which the metal ion coordination with the phosphoryl and carbonyl groups and the intrinsic properties of phosphoryl group might be the key factors responsible for this novel migration. Copyright (C) 2011 John Wiley & Sons, Ltd.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China[20972130, 20805037, 20732004]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-BLACKWELLzh_CN
dc.titleA novel methyl migration to the phosphoryl group with the formation of cyclic aminoacylphosphoramidates in electrospray ionization tandem mass spectra of amino acid ester phosphoramidates of antiviral nucleosideszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record