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dc.contributor.authorSun, Lingbin
dc.contributor.authorZuo, Zhenghong
dc.contributor.authorLuo, Hongmin
dc.contributor.authorChen, Meng
dc.contributor.authorZhong, Yuanfu
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.contributor.authorWang, Chonggan
dc.contributor.author王重刚
dc.date.accessioned2012-03-08T05:19:51Z
dc.date.available2012-03-08T05:19:51Z
dc.date.issued2011-11-07
dc.identifier.citationEnviron Sci Technol. 2011 Dec 1;45(23):10212-8zh_CN
dc.identifier.issn0013-936X
dc.identifier.urihttp://dx.doi.org/doi:10.1021/es202684w
dc.identifier.uriWOS:000297382700055
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11664
dc.description.abstractPhenanthrene (PHE) is one of the most abundant polycyclic aromatic hydrocarbons in the aquatic environment. This study was conducted to investigate the effects of PHE at environmentally relevant concentrations on testicular development in male Sebastiscus marmoratus. After SO days exposure, the gonadosomatic indices and percentage of sperm produced showed a U-shaped dose response. The levels of salmon-type gonadotropin releasing hormone, follicle-stimulating hormone, luteinizing hormone mRNA, 17 beta-estradiol, and gamma-glutamyl transpeptidase activity all showed a U-shaped dose response, which dearly demonstrated the U-shaped effects of PHE exposure on spermatogenesis and also elucidated the action pathway. This result would bring a difficulty and a challenge to any risk assessment of PHE exposure to the reproductive health of fishes. Thus far, there has been no ready explanation for a U-shaped dose-response curve, which is well recognized as a hormetic phenomenon for many hormones, drugs, and toxic compounds. In the present study, PHE accumulation in the brain showed an inverse U-shaped increase compared to the control. Glutathione S-transferase activity in the brain showed a U-shaped dose-response, which was related with the PHE accumulation. These results have given a reasonable explanation for the U-shaped dose-response via alteration of biotransformation enzyme activity in the brain.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China[40476049]; Natural Scientific Fund of Fujian Province, China[2009J01225]; Program for Changjiang Scholars and Innovative Research Team in University[IRT0941]zh_CN
dc.language.isoenzh_CN
dc.publisherAMER CHEMICAL SOCzh_CN
dc.titleChronic Exposure to Phenanthrene Influences the Spermatogenesis of Male Sebastiscus marmoratus: U-Shaped Effects and the Reason for Themzh_CN
dc.typeArticlezh_CN


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