Production of monodisperse epigallocatechin gallate (EGCG) microparticles by spray drying for high antioxidant activity retention
Fu, Nan（Monash Univ, Dept Chem Engn）
Zhou, Zihao（Monash Univ, Dept Chem Engn）
Jones, Tyson Byrne（Monash Univ, Dept Chem Engn）
Tan, Timothy T. Y.（Nanyang Technol Univ, Div Chem & Biomol Engn）
Wu, Winston Duo（Monash Univ, Dept Chem Engn）
Lin, Sean Xuqi（Monash Univ, Dept Chem Engn）
Chen, Xiao Dong
Chan, Peggy P. Y.（Monash Univ, Dept Chem Engn）
- 化学化工－已发表论文 
Epigallocatechin gallate (EGCG) originated from green tea is well-known for its pharmaceutical potential and antiproliferating effect on carcinoma cells. For drug delivery, EGCG in a micro-/nanoparticle form is desirable for their optimized chemopreventive effect. In this study, first time reports that EGCG microparticles produced by low temperature spray drying can maintain high antioxidant activity. A monodisperse droplet generation system was used to realize the production of EGCG microparticles. EGCG micropartides were obtained with narrow size distribution and diameter of 30.24 +/- 1.88 mu M and 43.39 +/- 0.69 mu M for pure EGCG and lactose-added EGCG, respectively. The EC50 value (the amount of EGCG necessary to scavenge 50% of free radical in the medium) of spray dried pure EGCG particles obtained from different temperature is in the range of 3.029-3.075 mu M compared to untreated EGCG with EC50 value of 3.028 mu M. Varying the drying temperatures from 70 degrees C and 130 degrees C showed little detrimental effect on EGCG antioxidant activity. NMR spectrum demonstrated the EGCG did not undergo chemical structural change after spray drying. The major protective mechanism was considered to be: (1) the use of low temperature and (2) the heat loss from water evaporation that kept the particle temperature at low level. With further drier optimization, this monodisperse spray drying technique can be used as an efficient and economic approach to produce EGCG micro-/nanoparticles. Published by Elsevier B.V.
CitationINTERNATIONAL JOURNAL OF PHARMACEUTICS，2011,413（1-2）：155-166
Showing items related by title, author, creator and subject.
Wu, Winston Duo（Monash Univ, Dept Chem Engn）; Amelia, Ria（Monash Univ, Dept Chem Engn）; Hao, Na（Monash Univ, Dept Chem Engn）; Selomulya, Cordelia（Monash Univ, Dept Chem Engn）; Zhao, Dongyuan（Fudan Univ, Dept Chem）; Chiu, Yu-Lung ( Univ Birmingham, Sch Met & Mat）; Chen, Xiao Dong; 陈晓东 (WILEY-BLACKWELL, 2011-06-19)Generation of uniform micro-particles containing (i) pure lactose; (ii) silica nanoparticles and lactose; (iii) silica nanoparticlesllactose doped with Eu(III) have been successfully achieved using a novel spray dryer with ...
Reaction Engineering Approach (REA) to model the drying kinetics of droplets with different initial sizes-experiments and analyses Fu, Nan（Monash Univ, Dept Chem Engn）; Woo, Meng Wai（Monash Univ, Dept Chem Engn）; Lin, Sean Xu Qi（Monash Univ, Dept Chem Engn）; Zhou, Zihao（Monash Univ, Dept Chem Engn）; Chen, Xiao Dong; 陈晓东 (PERGAMON-ELSEVIER SCIENCE LTD, 2011-01-13)Droplets with different initial sizes, which are typical in conventional liquid atomization for spray drying applications, will result in varying drying and crust formation histories. It is essential for any droplet drying ...
Amelia, Ria（Monash Univ, Dept Chem Engn）; Wu, Winston Duo（Monash Univ, Dept Chem Engn）; Cashion, John（Monash Univ, Dept Phys）; Bao, Peite（Univ Sydney, Australian Ctr）; Zheng, Rongkun（Univ Sydney, Australian Ctr）; Chen, Xiao Dong; 陈晓东; Selomulya, Cordelia（Monash Univ, Dept Chem Engn） (PERGAMON-ELSEVIER SCIENCE LTD, 2011-08-07)Microfluidic spray drying is a versatile route to synthesize functional particles, as the technique is scalable with sufficient yields for practical use and easy product recovery, whilst allowing for subsequent processing ...