Sensitive and selective off-on rhodamine hydrazide fluorescent chemosensor for hypochlorous acid detection and bioimaging
Date
2011-05-06Author
Zhang, Zhen
Zheng, Yan
Hang, Wei
杭纬
Yan, Xiaomei
颜晓梅
Zhao, Yufen
赵玉芬
Collections
- 化学化工-已发表论文 [14469]
Abstract
A rhodamine 6G hydrazide fluorescent chemosensor was prepared for the rapid HOCl detection in aqueous media. The system makes good use of the irreversible HOCl-mediated selective oxidation reaction to generate fluorescent response proportional to the amount of HOCl in neutral buffer. This probe exhibits great photostability, high sensitivity, and good selectivity for HOCl over other reactive species and most of the common metal ions. Furthermore, the probe is cell membrane permeable, and its applicability has been successfully demonstrated for fluorescence imaging of both exogenous and endogenous HOCl within living cells. Cytotoxicity assays prove that this probe is almost nontoxic to the cultured cell lines under the experimental conditions. (C) 2011 Elsevier B.V. All rights reserved.
Citation
TALANTA,2011,85(1):779-786URI
http://dx.doi.org/doi:10.1016/j.talanta.2011.04.078WOS:000292848900111
https://dspace.xmu.edu.cn/handle/2288/11578