dc.contributor.author | Ruan, Shu-Tang | |
dc.contributor.author | Luo, Jie-Min | |
dc.contributor.author | Du, Yu | |
dc.contributor.author | Huang, Pei-Qiang | |
dc.contributor.author | 黄培强 | |
dc.date.accessioned | 2012-02-26T04:45:15Z | |
dc.date.available | 2012-02-26T04:45:15Z | |
dc.date.issued | 2011-07-19 | |
dc.identifier.citation | Org. Lett., 2011, 13 (18): 4938–4941 | zh_CN |
dc.identifier.issn | 1523-7060 | |
dc.identifier.uri | http://dx.doi.org/doi:10.1021/ol2020384 | |
dc.identifier.uri | https://dspace.xmu.edu.cn/handle/2288/11512 | |
dc.identifier.uri | WOS:000294703900048 | |
dc.description.abstract | Asymmetric vinylogous Mannich reaction (VMR) of 2-(tert-butyldimethylsilyloxy)furan (TBSOF, 1) with (R(S))- or (S(S))-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds. | zh_CN |
dc.description.sponsorship | National Basic Research Program (973 Program) of China[2010CB833200]; NSF of China[20832005, 21072160] | zh_CN |
dc.language.iso | en | zh_CN |
dc.publisher | AMER CHEMICAL SOC | zh_CN |
dc.title | Asymmetric Vinylogous Mannich Reactions: A Versatile Approach to Functionalized Heterocycles | zh_CN |
dc.type | Article | zh_CN |