Asymmetric Vinylogous Mannich Reactions: A Versatile Approach to Functionalized Heterocycles

dc.contributor.author	Ruan, Shu-Tang
dc.contributor.author	Luo, Jie-Min
dc.contributor.author	Du, Yu
dc.contributor.author	Huang, Pei-Qiang
dc.contributor.author	黄培强
dc.date.accessioned	2012-02-26T04:45:15Z
dc.date.available	2012-02-26T04:45:15Z
dc.date.issued	2011-07-19
dc.identifier.citation	Org. Lett., 2011, 13 (18)： 4938–4941	zh_CN
dc.identifier.issn	1523-7060
dc.identifier.uri	http://dx.doi.org/doi:10.1021/ol2020384
dc.identifier.uri	https://dspace.xmu.edu.cn/handle/2288/11512
dc.identifier.uri	WOS:000294703900048
dc.description.abstract	Asymmetric vinylogous Mannich reaction (VMR) of 2-(tert-butyldimethylsilyloxy)furan (TBSOF, 1) with (R(S))- or (S(S))-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds.	zh_CN
dc.description.sponsorship	National Basic Research Program (973 Program) of China[2010CB833200]; NSF of China[20832005, 21072160]	zh_CN
dc.language.iso	en	zh_CN
dc.publisher	AMER CHEMICAL SOC	zh_CN
dc.title	Asymmetric Vinylogous Mannich Reactions: A Versatile Approach to Functionalized Heterocycles	zh_CN
dc.type	Article	zh_CN