Show simple item record

dc.contributor.authorRuan, Shu-Tang
dc.contributor.authorLuo, Jie-Min
dc.contributor.authorDu, Yu
dc.contributor.authorHuang, Pei-Qiang
dc.contributor.author黄培强
dc.date.accessioned2012-02-26T04:45:15Z
dc.date.available2012-02-26T04:45:15Z
dc.date.issued2011-07-19
dc.identifier.citationOrg. Lett., 2011, 13 (18): 4938–4941zh_CN
dc.identifier.issn1523-7060
dc.identifier.urihttp://dx.doi.org/doi:10.1021/ol2020384
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11512
dc.identifier.uriWOS:000294703900048
dc.description.abstractAsymmetric vinylogous Mannich reaction (VMR) of 2-(tert-butyldimethylsilyloxy)furan (TBSOF, 1) with (R(S))- or (S(S))-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds.zh_CN
dc.description.sponsorshipNational Basic Research Program (973 Program) of China[2010CB833200]; NSF of China[20832005, 21072160]zh_CN
dc.language.isoenzh_CN
dc.publisherAMER CHEMICAL SOCzh_CN
dc.titleAsymmetric Vinylogous Mannich Reactions: A Versatile Approach to Functionalized Heterocycleszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record