The prolyl isomerase Pin1 is overexpressed in human esophageal cancer
- 化学化工－已发表论文 
Peptidyl-prolyl isomerase Pint specifically catalyzes the cis/trans-isomerization of proline in the target sequence of phosphorylated Ser/Thr-Pro in over 50 critical regulatory proteins. Pin1 is abnormally overexpressed in a range of human cancers, including lung, breast, colon and prostate cancers. However, few reports of Pint overexpression are currently available in clinical samples. Therefore, we examined the expression of Pin I and p53 in non-pathological human tissues and esophageal cancer tissues. In esophageal cancer tissues, Pin I and p53 immunoreactivity was detected in cancer cells in 67 and 58% of cases, respectively. Moreover, Pin1 and p53 immunoreactivity was significantly correlated with lymph node-positive disease and more advanced cancer stage. The results demonstrated that high expression levels of Pint correlated with high levels of p53. Therefore, Pin I is suggested to play key roles in the regulation of esophageal cancer.