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dc.contributor.authorTan, Weihong(Hunan Univ, Coll Chem & Chem Engn)
dc.contributor.authorWang, Hui( Univ Florida, UF Genet Inst)
dc.contributor.authorChen, Yan
dc.contributor.authorZhang, Xiaobing(Hunan Univ, Coll Chem & Chem Engn)
dc.contributor.authorZhu, Haizhen(Hunan Univ, Coll Chem & Chem Engn)
dc.contributor.authorYang, Chaoyong
dc.contributor.author杨朝勇
dc.contributor.authorYang, Ronghua(Hunan Univ, Coll Chem & Chem Engn)
dc.contributor.authorLiu, Chen( Univ Florida, UF Genet Inst)
dc.date.accessioned2012-02-17T08:07:25Z
dc.date.available2012-02-17T08:07:25Z
dc.date.issued2011-08-06
dc.identifier.citationTRENDS IN BIOTECHNOLOGY,2011,29(12):234-240zh_CN
dc.identifier.issn0167-7799
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.tibtech.2011.06.009
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11442
dc.identifier.uriWOS:000297878000006
dc.description.abstractThe active targeting of drugs in a cell-, tissue- or disease-specific manner represents a potentially powerful technology with widespread applications in medicine, including the treatment of cancers. Aptamers have properties such as high affinity and specificity for targets, easy chemical synthesis and modification, and rapid tissue penetration. They have become attractive molecules in diagnostics and therapeutics rivaling and, in some cases, surpassing other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes.zh_CN
dc.description.sponsorshipNational Key Scientific Program of China[2011CB911000]; China National Grand Program[2009ZX10004-312]; National Institutes of Health[GM066137, GM079359, CA133086]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE LONDONzh_CN
dc.titleMolecular aptamers for drug deliveryzh_CN
dc.typeArticlezh_CN


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