Molecular aptamers for drug delivery
Date
2011-08-06Author
Tan, Weihong(Hunan Univ, Coll Chem & Chem Engn)
Wang, Hui( Univ Florida, UF Genet Inst)
Chen, Yan
Zhang, Xiaobing(Hunan Univ, Coll Chem & Chem Engn)
Zhu, Haizhen(Hunan Univ, Coll Chem & Chem Engn)
Yang, Chaoyong
杨朝勇
Yang, Ronghua(Hunan Univ, Coll Chem & Chem Engn)
Liu, Chen( Univ Florida, UF Genet Inst)
Collections
- 化学化工-已发表论文 [14469]
Abstract
The active targeting of drugs in a cell-, tissue- or disease-specific manner represents a potentially powerful technology with widespread applications in medicine, including the treatment of cancers. Aptamers have properties such as high affinity and specificity for targets, easy chemical synthesis and modification, and rapid tissue penetration. They have become attractive molecules in diagnostics and therapeutics rivaling and, in some cases, surpassing other molecular probes, such as antibodies. In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes.
Citation
TRENDS IN BIOTECHNOLOGY,2011,29(12):234-240URI
http://dx.doi.org/doi:10.1016/j.tibtech.2011.06.009https://dspace.xmu.edu.cn/handle/2288/11442
WOS:000297878000006