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dc.contributor.authorJi, ZL
dc.contributor.author纪志梁
dc.contributor.authorLi, ZR
dc.contributor.authorWang, JF
dc.contributor.authorCai, CZ
dc.contributor.authorHan, LY
dc.contributor.authorZheng, CJ
dc.contributor.authorChen, YZ
dc.date.accessioned2011-12-06T08:55:53Z
dc.date.available2011-12-06T08:55:53Z
dc.date.issued2006
dc.identifier.citationDrug Design & Discovery, Vol. 3, No. 3. (April 2006), pp. 200-204.zh_CN
dc.identifier.issn1570-1808
dc.identifier.urihttp://dx.doi.org/doi:10.2174/157018006776286970
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11338
dc.description.abstractThe odds of drug hit identification in screening are closely related to the diversity of libraries or the availability of focused libraries. There are no truly diverse libraries and it is difficult to design focused libraries without sufficient information. Hence alternative approaches need to be explored for enhancing the odds of hit discovery from existing libraries. Protein homologs have been used collectively targeted in inhibitor design and other discovery applications by exploiting the correlation between protein homologs and their ligands from specific compound classes. A receptor-homolog-based screening scheme may be derived as a strategy to potentially increase the odds of hit identification.zh_CN
dc.language.isoenzh_CN
dc.publisherBENTHAM SCIENCE PUBL LTDzh_CN
dc.subjectdrug designzh_CN
dc.subjectdrug discoveryzh_CN
dc.subjecthigh throughput screeningzh_CN
dc.subjecthomologszh_CN
dc.subjectvirtual screeningzh_CN
dc.titleIncreasing the odds of drug hit identification by screening against receptor homologs?zh_CN
dc.typeArticlezh_CN


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