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dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorCai, Jiali
dc.contributor.authorWang, Xinli
dc.contributor.authorLi, Bowen
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.date.accessioned2011-12-06T02:59:05Z
dc.date.available2011-12-06T02:59:05Z
dc.date.issued2009
dc.identifier.citationAQUATIC TOXICOLOGY,Volume 92, Issue 1, 2 April 2009, Pages 44-49zh_CN
dc.identifier.issn0166-445X
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.aquatox.2009.01.008
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11325
dc.description.abstractTributyltin (TBT), widely used as an antifouling biocide, is the most abundant pesticide in coastal environments. Trimethyltin (TMT) is a potent neurotoxicant of a mechanism of action yet to be uncovered. The neurotoxicity of TBT and TMT on the brain of marine fish Sebastiscus marmoratus was investigated in this study. The results showed that TBT and TMT can modulate amino acid neurotransmitters and N-methyl-D-aspartate receptor (NMDAR) signaling pathway in the brain of marine fish in a different manner. TBT did not increase the content of the amino acid neurotransmitters except gamma-aminobutyricd acid (GABA). TMT increased the content of aspartate (Asp), glutamate (Glu) and GABA in a dose-dependent manner. The expression of NADAR and components on its signaling pathway, such as calmodulin, calmodulin-dependent kinase II (CaMKII) and cAMP-response element-binding (CREB) protein was significantly decreased in a dose-dependent manner after TBT exposure. However, the low dose of TMT exposure up-regulate rather than down-regulate the expression of NMDAR and other genes of its pathway. It is suggested that the Glu-NMDAR pathway plays a role in the mechanism for the brain injury in marine fish after TBT or TMT exposure. The alteration of expression of glutamatergic receptor NMDAR and components on its signaling pathway accompanied with the change of total brain transmitter level indicated the importance of glutamatergic system in organotin toxicity. (c) 2009 Elsevier B.V. All rights reserved.zh_CN
dc.description.sponsorshipNational Natural Science Foundation [40606027]; State Key Laboratory of Marine Environmental Science (Xiamen University), China [MEL0606]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectTributyltinzh_CN
dc.subjectTrimethyltinzh_CN
dc.subjectNeurotoxicityzh_CN
dc.subjectGlutamatezh_CN
dc.subjectN-methyl-D-aspartate (NMDA) receptorzh_CN
dc.subjectSebastiscus marmoratuszh_CN
dc.titleAcute administration of tributyltin and trimethyltin modulate glutamate and N-methyl-D-aspartate receptor signaling pathway in Sebastiscus marmoratuszh_CN
dc.typeArticlezh_CN


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