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dc.contributor.authorYan, Feihuan
dc.contributor.authorChen, Yufang
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.contributor.authorYang, Zengming
dc.contributor.author杨增明
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.date.accessioned2011-12-06T00:27:33Z
dc.date.available2011-12-06T00:27:33Z
dc.date.issued2009
dc.identifier.citationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,Volume 28, Issue 1, July 2009, Pages 19-24zh_CN
dc.identifier.issn1382-6689
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.etap.2009.01.011
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11307
dc.description.abstractThe effects of tributyltin (TBT) on sperm parameters and epididymal function were investigated following oral doses of 0.5, 5 and 50 mu g/kg every 3 days for 45 days to male KM mouse. The TBT-treated groups showed a significant decrease in sperm counts and a significant increase in sperm abnormality both in a dose-dependent manner. The expression of matrilysin (MMP7) transcript in epididymis of mice exposed to TBT was significantly decreased in 5 and 50 mu g/kg group. There was a dose-dependent decline trend in the acid phosphatase activity, which somewhat relates with the TBT-induced increase in sperm abnormality. Acrosin and lactate dehydrogenase-X isoenzyme (LDH-X) activities from the cauda epididymal spermatozoa showed a dose-dependent decrease in the TBT groups. The result indicates a suppression of essential sperm maturational processes that precede the penetration of the oocyte by the sperm, such as capacitation and acrosome reaction. These results suggest that TBT could cause a spermatotoxic effects, the decline of sperm count and quality caused by TBT suggests that this chemical could impair fertility in animals. (C) 2009 Elsevier B.V. All rights reserved.zh_CN
dc.description.sponsorshipNational Key Technology R&D Program of China [2007BAC27B02]; National Basic Research Program of China [2006CB504005]zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectTributyltinzh_CN
dc.subjectSpermzh_CN
dc.subjectAcrosinzh_CN
dc.subjectMMP7zh_CN
dc.subjectAcid phosphatasezh_CN
dc.subjectLactate dehydrogenase-X isoenzymezh_CN
dc.titleEffects of tributyltin on epididymal function and sperm maturation in micezh_CN
dc.typeArticlezh_CN


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