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Effects of tributyltin on epididymal function and sperm maturation in mice

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Effects of tributyltin on epididymal function and sperm maturation in mice.htm (413bytes)
Date
2009
Author
Yan, Feihuan
Chen, Yufang
Zuo, Zhenghong
左正宏
Chen, Yixin
陈奕欣
Yang, Zengming
杨增明
Wang, Chonggang
王重刚
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  • 生命科学-已发表论文 [5877]
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Abstract
The effects of tributyltin (TBT) on sperm parameters and epididymal function were investigated following oral doses of 0.5, 5 and 50 mu g/kg every 3 days for 45 days to male KM mouse. The TBT-treated groups showed a significant decrease in sperm counts and a significant increase in sperm abnormality both in a dose-dependent manner. The expression of matrilysin (MMP7) transcript in epididymis of mice exposed to TBT was significantly decreased in 5 and 50 mu g/kg group. There was a dose-dependent decline trend in the acid phosphatase activity, which somewhat relates with the TBT-induced increase in sperm abnormality. Acrosin and lactate dehydrogenase-X isoenzyme (LDH-X) activities from the cauda epididymal spermatozoa showed a dose-dependent decrease in the TBT groups. The result indicates a suppression of essential sperm maturational processes that precede the penetration of the oocyte by the sperm, such as capacitation and acrosome reaction. These results suggest that TBT could cause a spermatotoxic effects, the decline of sperm count and quality caused by TBT suggests that this chemical could impair fertility in animals. (C) 2009 Elsevier B.V. All rights reserved.
Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,Volume 28, Issue 1, July 2009, Pages 19-24
URI
http://dx.doi.org/doi:10.1016/j.etap.2009.01.011
https://dspace.xmu.edu.cn/handle/2288/11307

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