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dc.contributor.authorLi, Guang
dc.contributor.authorZhang, Juyong
dc.contributor.authorSun, Yi
dc.contributor.authorWang, Hua
dc.contributor.authorWang, Yiquan
dc.contributor.author王义权
dc.date.accessioned2011-12-05T08:37:59Z
dc.date.available2011-12-05T08:37:59Z
dc.date.issued2009
dc.identifier.citationMol Biol Evol (2009) 26 (7): 1619-1630.zh_CN
dc.identifier.issn0737-4038
dc.identifier.urihttp://dx.doi.org/doi:10.1093/molbev/msp074
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11299
dc.description.abstractInterferon (IFN)-inducible GTPases currently include four families of proteins: myxovirus resistant proteins (Mxs), guanylate-binding proteins (GBPs), immunity-related GTPase proteins (IRGs), and very large inducible GTPase proteins (VLIGs). They are all under conserved regulation by IFNs in humans and mice and play a critical role in preventing microbial infections. However, differences between vertebrates are poorly characterized, and their evolutionary origins have not been studied in detail. In this study, we performed comparative genomic analysis of the four families in 18 representative animals that yielded several unexpected results. Firstly, we found that Mx, GBP, and IRG protein families arose before the divergence of chordate subphyla, but VLIG emerged solely in vertebrates. Secondly, IRG, GBP, and VLIG families have experienced a high rate of gene gain and loss during the evolution, with the GBP family being lost entirely in two pufferfish and VLIG family lost in primates and carnivores. Thirdly, the regulation of these genes by IFNs is highly conserved throughout vertebrates although the VLIG protein sequences in fish have lost the first 870 amino acid residues. Finally, amphioxus IFN-inducible GTPase genes are all highly expressed in immune-related organs such as gill, liver, and intestine and are upregulated after challenge with PolyI:C and pathogens, although no IFNs or their receptors were detected in the current amphioxus genome database. These results suggest that IFN-inducible GTPase genes play conserved immune functions both in vertebrates and in cephalochordates.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [30830023]; Ministry of Education, China [20070384041]zh_CN
dc.language.isoenzh_CN
dc.publisherOXFORD UNIV PRESSzh_CN
dc.subjectIFN-inducible GTPase protein-coding geneszh_CN
dc.subjectimmune functionzh_CN
dc.subjectvertebrateszh_CN
dc.subjectamphioxuszh_CN
dc.subjectevolutionzh_CN
dc.titleThe Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and Cephalochordateszh_CN
dc.typeArticlezh_CN


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