Show simple item record

dc.contributor.authorYuan, Lin
dc.contributor.authorLin, Xiang
dc.contributor.authorZhao, Pei-Ji
dc.contributor.authorMa, Juan
dc.contributor.authorHuang, Yao-Jian
dc.contributor.author黄耀坚
dc.contributor.authorShen, Yue-Mao
dc.contributor.author沈月毛
dc.date.accessioned2011-12-05T08:23:04Z
dc.date.available2011-12-05T08:23:04Z
dc.date.issued2009
dc.identifier.citationHelvetica Chimica Acta,vol92,issue6,pp1184-1190zh_CN
dc.identifier.issn0018-019X
dc.identifier.urihttp://dx.doi.org/doi:10.1002/hlca.200800416
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11298
dc.description.abstractFour new polyketides, namely rel-(2R,3S,4R,5R)-4-ethyltetrahydro-3-methyl-5-propylfuran-2,3-diol (1), methyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (2), butyl 5-[(1R)-1-hydroxyethyl]-gamma-oxofuran-2-butanoate (3), and 3,4-dihydro-5'-[(1R)-1-hydroxyethyl][2,2'-bifuran]-5(2H)-one (4), together with three known ones, 5-[(1R)-1-hydroxethyl)-gamma-oxofuran-2-butanoic acid (5), phomopsolide B (6), and (2S,3S)-3,6-dihydro-6-oxo-2-[(1E)-2-{(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethenyl)-2H-pyran-3-yl (2E)-2-methylbut-2-enoate (7), were isolated from the submerged cultures of the endophytic fungal strain Diaporthe sp. XZ-07 of Camptotheca acuminate. The structures of the new compounds were established by 1D- and 2D-NMR and MS data and by Mosher's method. Compound 6 significantly inhibited the growth of human-tumor HeLa cells with an IC50 of 5.7 mu g/ml by the MTT assay (MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide).zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-V C H VERLAG GMBHzh_CN
dc.titleNew Polyketides from Endophytic Diaporthe sp XZ-07zh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record