Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: observation of stereoelectronic effects
Date
2004-12Author
Ming-De Chen
Ming-Zhu He
Xiang Zhou
Li-Qiang Huang
Yuan-Ping Ruan
阮源萍
Pei-Qiang Huang
黄培强
Collections
- 化学化工-已发表论文 [14469]
Abstract
Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin-1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions. (C) 2004 Elsevier Ltd. All rights reserved.