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dc.contributor.authorShi, Song-Lin
dc.contributor.author石松林
dc.contributor.authorLiang, Ying
dc.contributor.author梁盈
dc.contributor.authorLi, Qi-Fu
dc.contributor.author李祺福
dc.contributor.authorJing, Guang-Jun
dc.contributor.authorWang, San-Ying
dc.contributor.authorZhang, Xiu-Yan
dc.contributor.author张秀艳
dc.contributor.authorWu, Fu-Yun
dc.date.accessioned2011-11-01T00:43:52Z
dc.date.available2011-11-01T00:43:52Z
dc.date.issued2010-09-01
dc.identifier.citationJournal of Cellular Biochemistry,Volume 111, Issue 1, pages 67–74zh_CN
dc.identifier.issn0730-2312
dc.identifier.urihttp://dx.doi.org/doi:10.1002/jcb.22663
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11099
dc.description.abstractIn this study, female and male Thais clavigera whelks were exposed to aqueous and dietary (using oysteis as the prey) tributyltin gm for up to 45 days. followed by a 30-day depuration, in order to examine the gender differences in TBT accumulation and transformation The metabolites of TBT [dibutyltin (DBT) and monobutyltin (MBT)] were also measured in different tissues of the whelks (digestive, reproductive and remaining organs) during the exposure and depuration periods By the end of the exposure period. all of the female whelks developed imposex after TBT exposure, and both the relative penis size index and the vas deferens sequence index were positively correlated with the tissue burden of TBT However, biomagnification of TBT did not occur in the whelks. TBT was rapidly accumulated in their digestive and reproductive organs from both routes of exposure, and both elimination and biotransformation of TBT were also rapid The redistribution of TBT among tissues was obvious during the exposure period but negligible during depuration MBT was generally the major metabolite in each tissue, indicating a significant metabolism of TBT by the whelks Accumulation, transformation, as well as elimination, were more significant following dietary exposure than following aqueous exposure In particular, we observed gender-related differences in the biokinetics of TBT Rapid biotransformation and elimination of TBT were detected in the male whelks, while the female whelks had higher bioaccumulation but lower elimination of TBT in their reproductive organs Internal remobilization of TBT from digestive to reproductive organs was also more obvious in the females, indicating that the reproductive organs of females were the main targets of TBT accumulation (C) 2010 Elsevier B.V All rights reservedzh_CN
dc.description.sponsorshipNational Natural Science Foundation of China [40476048]; 863 project [2007AA09Z126]; Marine Public Welfare Project of China [200805090]zh_CN
dc.language.isoenzh_CN
dc.publisherWILEY-LISSzh_CN
dc.subjectNUCLEOPHOSMINzh_CN
dc.subjectNUCLEAR MATRIXzh_CN
dc.subjectHUMAN NEUROBLASTOMAzh_CN
dc.subjectCELL DIFFERENTIATIONzh_CN
dc.titleLocalization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acidzh_CN
dc.typeArticlezh_CN


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