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dc.contributor.authorHuang, YJ
dc.contributor.author黄耀坚
dc.contributor.authorWang, JF
dc.contributor.authorLi, GL
dc.contributor.authorZheng, ZH
dc.contributor.author郑忠辉
dc.contributor.authorSu, WJ
dc.contributor.author苏文金
dc.date.accessioned2011-10-31T08:31:58Z
dc.date.available2011-10-31T08:31:58Z
dc.date.issued2001
dc.identifier.citationFEMS Immunology and Medical Microbiology 31 (2001) 163-167zh_CN
dc.identifier.issn0928-8244
dc.identifier.urihttp://dx.doi.org/doi:10.1111/j.1574-695X.2001.tb00513.x
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11079
dc.description.abstractThe purpose of this work was to screen the endophytic fungi having antitumor or antifungal activity, which were isolated from the inner barks of three kinds of pharmaceutical plants, Taxus mairei, Cephalataxus fortunei and Torreya grandis, collected from Fujian province, China. Antitumor activity was studied by the MTT assay and antifungal activity was determined by observing fungal growth inhibition. 13.4% of endophytic fungi fermentation broths displayed cytotoxic activity on HL-60 cells at and below a dilution of 1:50, and 6.4% on KB cells. 52.3% of endophytic fungi fermentation broths displayed growth inhibition on at least one pathogenic fungi, such as Neurospora sp., Trichoderma sp. and Fusarium sp. Among all endophytic, fungi isolated, the genus Paecilomyces sp. has the highest positive rate of antitumor and antifungal activity. These results indicate that endophytic fungi could be a promising source for antitumor and antifungal bioactive agents. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectendophytic funguszh_CN
dc.subjectantitumorzh_CN
dc.subjectantifungalzh_CN
dc.titleAntitumor and antifungal activities in endophytic fungi isolated from pharmaceutical plants Taxus mairei, Cephalataxus fortunei and Torreya grandiszh_CN
dc.typeArticlezh_CN


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