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dc.contributor.authorChen, RC
dc.contributor.author陈瑞川
dc.contributor.authorSu, JH
dc.contributor.authorGao-Liang, OY
dc.contributor.author欧阳高亮
dc.contributor.authorCai, KX
dc.contributor.authorLi, JQ
dc.contributor.authorXie, XG
dc.date.accessioned2011-10-31T02:07:46Z
dc.date.available2011-10-31T02:07:46Z
dc.date.issued2002
dc.identifier.citationPlanta Med 2002; 68(4): 370-372zh_CN
dc.identifier.issn0032-0943
dc.identifier.urihttp://dx.doi.org/doi:10.1055/s-2002-26759
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11067
dc.description.abstractIsoverbascoside, a phenylethanoid glycoside, was isolated from Chinese folk medicine herb Pedicularis striata Pall. Here we report that isoverbascoside is capable of inducing differentiation in human hepatocellular carcinoma (HCC) cell line SMMC-7721. When treated with isoverbascoside, the proliferation of SMMC-7721 cells was markedly inhibited in a dose- and time-dependent manner, and the average cell population doubling time was delayed. Exposure of cells to 20 pmol/l isoverbascoside led to the decline of colony formation efficiency on soft agar, induced G(0)/G(1) arresting, and resulted in the decrease of gamma-glutamyltransferase (SGT) activity and the increase of tyrosine aminotransferase (TAT) activity, two marker enzymes, respectively, representing HCC malignance and differentiation stage. These results suggest that isoverbascoside possess the activity of inducing differentiation in SMMC-7721 cells.zh_CN
dc.language.isoenzh_CN
dc.publisherGEORG THIEME VERLAG KGzh_CN
dc.titleInduction of differentiation in human hepatocarcinoma cells by isoverbascosidezh_CN
dc.typeArticlezh_CN


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