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dc.contributor.authorShao, HJ
dc.contributor.authorChen, L
dc.contributor.author陈亮
dc.contributor.authorShen, MS
dc.contributor.authorYu, GF
dc.date.accessioned2011-10-26T08:51:00Z
dc.date.available2011-10-26T08:51:00Z
dc.date.issued2003
dc.identifier.citationActa Virol. 2003;47(4):217-21zh_CN
dc.identifier.issn0001-723X
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/11013
dc.description.abstractDNA vaccines have been widely used as effective means of eradicating a variety of viruses, parasites, bacteria as well as means of alleviating allergic and autoimmune diseases and tumors. As interleukin 1 (IL-1) plays an essential role in augmenting both cellular and humoral immune responses to foreign antigens, it may represent a good candidate for an adjuvant to DNA vaccines. Since the inflammatory activity of IL-1 may have a restricted application to DNA vaccines, we explored the possibility of augmenting immune response without unwanted inflammatory effect using IL-1beta 163-171 peptide, which is essential for IL-1 receptor 1 binding. A DNA fragment encoding the human IL-1beta 163-171 peptide of concern was fused to the Hepatitis B virus (HBV) core DNA vaccine, and injected into mice to analyze its immune responses. Compared with the control mice which received hepatitis B virus core antigen (HBcAg) alone, significant increase in not only the HBcAg-specific antibody response but also in T cell proliferation was observed in mice which received IL-1beta 163-171-HBcAg. These results suggest that the DNA fragment encoding the IL-1beta polypeptide of aa 163-171 might represent a good candidate for an adjuvant of DNA vaccines.zh_CN
dc.language.isoenzh_CN
dc.publisherSLOVAK ACADEMIC PRESS LTDzh_CN
dc.subjectinterleukin 1 betazh_CN
dc.subjecthepatitis B virus core antigenzh_CN
dc.subjectDNA vaccinezh_CN
dc.titleEnhancement of immune responses to the hepatitis B virus core protein through DNA vaccines with a DNA fragment encoding human IL-1 beta 163-171 peptidezh_CN
dc.typeArticlezh_CN


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