Show simple item record

dc.contributor.authorHong Li
dc.contributor.authorXue-Yi Le
dc.contributor.authorDai-Wen Pang
dc.contributor.authorHong Deng
dc.contributor.authorZheng-He Xu
dc.contributor.authorZhong-Hua Lin
dc.contributor.author林仲华
dc.date.accessioned2011-10-16T14:58:27Z
dc.date.available2011-10-16T14:58:27Z
dc.date.issued2005-09
dc.identifier.citationJOURNAL OF INORGANIC BIOCHEMISTRY,2005,99(11):2240-2247zh_CN
dc.identifier.issn0162-0134
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.jinorgbio.2005.08.005
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10939
dc.description.abstractDNA-binding properties of novel copper(II) complex [CU((L)-Phe)(TATP)(H2O)](+), where (L)-Phe = (L)-phenylalaninate and TATP = 1,4,8,9-tetra-aza-triphenylene are investigated using electronic absorption spectroscopy, fluorescence spectroscopy, voltammetry and viscosity measurement. It is found that the presence of calf thymus DNA results in a hypochromism and red shift in the electronic absorption, a quenching effect on fluorescence nature of ethidium bromide-DNA system, an enhanced response on voltammograms of [Co(phen)(3)](3+/2+)-DNA system, and an obvious change in viscosity of DNA. From absorption titration, fluorescence analysis and voltammetric measurement, the binding constant of the complex with DNA is calculated. The latter two methods reveal the stronger binding of [Cu((L)-Phe)(TATP)(H2O)](+) complex to double strand DNA by the moderate intercalation than [Co(phen)(3)](3+). Such a binding induces the cleavage of plasmid pBR322 DNA in the presence of H2O2. (c) 2005 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE INCzh_CN
dc.subjectcopper(II) complexzh_CN
dc.subjectL-phenylalaninatezh_CN
dc.subjecttetra-aza-triphenylenezh_CN
dc.subjectDNA-bindingzh_CN
dc.subjectcleavagezh_CN
dc.titleDNA-binding and cleavage studies of novel copper(II) complex with L-phenylalaninate and 1,4,8,9-tetra-aza-triphenylene ligandszh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record