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dc.contributor.authorPing, S
dc.contributor.authorWang, SY
dc.contributor.author王三英
dc.contributor.authorZhang, JY
dc.contributor.authorPeng, XX
dc.contributor.author彭宣宪
dc.date.accessioned2011-10-08T01:48:49Z
dc.date.available2011-10-08T01:48:49Z
dc.date.issued2005
dc.identifier.citationPERGAMON-ELSEVIER SCIENCE LTD,Volume 37, Issue 3, March 2005, Pages 616-627zh_CN
dc.identifier.issn1357-2725
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.biocel.2004.08.007
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10871
dc.description.abstractp62 is a cancer- associated antigen binding to mRNA encoding insulin-like growth factor 11 that was isolated by immunoscreening a cDNA expression library with autoantibodies from patients with hepatocellular carcinoma (HCC). In the present study, multiple methods including flow cytometry, confocal laser-scanning microscope, electron microscope were used to characterize the effect of ATRA on BGC-823 cells, which presented two phenotypes of differentiation and apoptosis in cells treated with 1.0 and 50 muM ATRA, respectively. Interestingly, we found that p62 was cytoplasmic in location, but it significantly decreased in cytoplasm and appeared in nucleus of cells when the cells were treated with 50 muM all-trans retinoic acid (ATRA) for 5 days. Furthermore, proteomics approach on differential nucleus proteins showed that the up-regulation and/or down-regulation of cell cycle proteins and IGF binding proteins were involved in the apoptosis of BGC-823 cells induced by ATRA. These results suggest that there is a significant association between expression and distribution of p62 and the growth arrest of tumor cells, in which p62 is associated with cell apoptosis induced by ATRA. (C) 2004 Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subjectp62zh_CN
dc.subjectall-trans retinoic acidzh_CN
dc.subjectapoptosiszh_CN
dc.subjectinsulin-like growth factor IIzh_CN
dc.titleEffect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cellszh_CN
dc.typeArticlezh_CN


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