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dc.contributor.authorYu, CL(Zhongshan University)
dc.contributor.authorDong, ML(Zhongshan University)
dc.contributor.authorWu, XK(Zhongshan University)
dc.contributor.authorLi, SG(Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854 )
dc.contributor.authorHuang, SF(Zhongshan University)
dc.contributor.authorSu, J(Zhongshan University)
dc.contributor.authorWei, JW(Zhongshan University)
dc.contributor.authorShen, Y(Zhongshan University)
dc.contributor.authorMou, CY( Zhongshan University)
dc.contributor.authorXie, XJ(Zhongshan University)
dc.contributor.authorLin, JG( Zhongshan University)
dc.contributor.authorYuan, SC(Zhongshan University)
dc.contributor.authorYu, XS(Zhongshan University)
dc.contributor.authorYu, YH(Zhongshan University)
dc.contributor.authorDu, JC(Zhongshan University)
dc.contributor.authorZhang, SC(Department of Marine Biotechnology, Ocean University of China, Qingdao, People’s Republic of China)
dc.contributor.authorPeng, XX
dc.contributor.author彭宣宪
dc.contributor.authorXiang, MQ( Department of Marine Biotechnology, Ocean University of China, Qingdao, People’s Republic of China)
dc.contributor.authorXu, AL( Zhongshan University)
dc.date.accessioned2011-10-05T09:59:23Z
dc.date.available2011-10-05T09:59:23Z
dc.date.issued2005
dc.identifier.citationThe Journal of Immunology,vol. 174 no. 6 3493-3500zh_CN
dc.identifier.issn0022-1767
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10844
dc.description.abstractin seeking evidence of the existence of adaptive immune system (AIS) in ancient chordate, cDNA clones of six libraries from a protochordate, the Chinese amphioxus, were sequenced. Although the key molecules such as TCR, MHC, Ig, and RAG in AIS have not been identified from our database, we demonstrated in this study the extensive molecular evidence for the presence of genes homologous to many genes that are involved in AIS directly or indirectly, including some of which may represent the putative precursors of vertebrate AIS-related genes. The comparative analyses of these genes in different model organisms revealed the different fates of these genes during evolution. Their gene expression pattern suggested that the primitive digestive system is the pivotal place of the origin and evolution of the AIS. Our studies support the general statement that AIS appears after the jawless/jawed vertebrate split. However our study further reveals the fact that AIS is in its twilight in amphioxus and the evolution of the molecules in amphioxus are waiting for recruitment by the emergence of AIS.zh_CN
dc.language.isoenzh_CN
dc.publisherAMER ASSOC IMMUNOLOGISTSzh_CN
dc.titleGenes "Waiting" for recruitment by the adaptive immune system: The insights from amphioxuszh_CN
dc.typeArticlezh_CN


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