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dc.contributor.authorShi, P
dc.contributor.authorHuang, ZW(Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200032, PR China)
dc.contributor.authorWang, SY
dc.contributor.author王三英
dc.contributor.authorZhang, JY(University of Texas, El Paso, TX, USA)
dc.contributor.authorPeng, XX
dc.contributor.author彭宣宪
dc.date.accessioned2011-10-05T09:16:43Z
dc.date.available2011-10-05T09:16:43Z
dc.date.issued2005
dc.identifier.citationCell Biol Int. 2005 Feb;29(2):127-31. Epub 2005 Jan 20zh_CN
dc.identifier.issn1065-6995
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.cellbi.2004.09.013
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10840
dc.description.abstractThe distribution of the cancer-associated protein p62 in human gastric carcinoma (BGC-823) cells was examined by confocal laser scanning microscopy and electron microscope immunocytochemistry. In control cells p62 was cytoplasmic in location and concentrated in the cytoplasmic matrix, but when cell growth was inhibited by treatment with 50 mu M all-trans-retinoic acid (ATRA) for 5 days, p62 expression decreased and the protein was translocated from cytoplasm to nucleus. Ultrastructural localization using gold particles showed that p62 was bond mainly to a linear structure in nucleus. The speculation that p62 binds Insulin-like growth factor (IGF)-II mRNA indicates its probable involvement in the posttranscriptional IGF-II mRNA processing and p62 could play a role in tumorgenesis by regulating the expression of IGF-II. Further studies will be needed to confirm this view. (C) 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTDzh_CN
dc.subjectp62zh_CN
dc.subjectBGC-823 cellszh_CN
dc.subjectconfocal microscopyzh_CN
dc.subjectelectron microscopyzh_CN
dc.subjectall-trans-retinoic acidzh_CN
dc.subjectinsulin-like growth factorzh_CN
dc.titleEffects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cellszh_CN
dc.typeArticlezh_CN


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