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dc.contributor.authorFan, YG(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorLiu, JR(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorWang, SY
dc.contributor.author王三英
dc.contributor.authorWang, HB(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorShi, FL(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorXiong, LH(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorHe, W(Guangzhou University of Traditional Chinese Medicine, Guangzhou)
dc.contributor.authorPeng, XX
dc.contributor.author彭宣宪
dc.date.accessioned2011-10-02T12:33:51Z
dc.date.available2011-10-02T12:33:51Z
dc.date.issued2005
dc.identifier.citationPERGAMON-ELSEVIER SCIENCE LTD,Volume 76, Issue 25, 6 May 2005, Pages 2893-2901zh_CN
dc.identifier.issn0024-3205
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.lfs.2004.10.059
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10818
dc.description.abstractOsteoporosis is a chronic condition chiefly affecting postmenopausal women, in whom the skeleton loses a significant percentage of its mineralized mass and mechanical resiliency, thereby becoming prone to fracture. Although the effect of the loss of estrogen on bone metabolism has been documented, its mechanism is still poorly understood. In the present proteomic study, we characterized the effect of estrogen deficiency on protein expression in rat bones. Using two-dimensional gel electrophoresis, mass spectrometry and rat protein database, we successfully identified three distinctly changed proteins named thioredoxin peroxidase 1, myosin light polypeptide 2 and ubiquitin-conjugating enzyme E-2-17 kD, among which ubiquitin-conjugating enzyme E2-17 kD has been documented to be an estrogen-related protein, but the other two are first reported to be osteoporosis-related proteins in the current study. These results provide valuable experimental evidences for the elucidation of the molecular mechanism of osteoporosis related to the loss of estrogen. (c) 2005 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subjectproteomicszh_CN
dc.subjectosteoporosiszh_CN
dc.subjectestrogenzh_CN
dc.subjectratzh_CN
dc.titleFunctional proteome of bones in rats with osteoporosis following ovariectomyzh_CN
dc.typeArticlezh_CN


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