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Inhibitory effects of 4-vinylbenzaldehyde and 4-vinylbenzoic acid on the activity of mushroom tyrosinase

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Inhibitory effects of 4-vinylbenzaldehyde and 4-vinylbenzoic acid on the activity of mushroom tyrosinase.htm (412bytes)
Date
2005
Author
Song, KK
Chen, QX
陈清西
Wang, Q
王勤
Qiu, L
Huang, H
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  • 生命科学-已发表论文 [5901]
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Abstract
Tyrosinase (EC 1.14.18.1) catalyzes both the hydroxylation of ryrosine into o-diphenols and the oxidation of o-diphenols into o-quinones which form brown or black pigments. Here, the inhibitory effects of 4-vinylbenzaldehyde and 4-vinylbenzoic acid on the activity of mushroom tyrosinase have been investigated. The results showed that both 4-vinylbenzaldehyde and 4-vinylbenzoic acid could inhibit both monophenolase activity and diphenolase activity of the enzyme. For the monophenolase activity, 4-vinylbenzoic acid could lengthen the lag time, but 4-vinylbenzaldehyde could not. Both 4-vinylbenzaldehyde and 4-vinylbenzoic acid decreased the steady-state activity, and the IC50 values were estimated as 93 mu M and 3.0 mM for monophenolase activity, respectively. For the diphenolase activity, the inhibitory capacity of 4-vinylbenzaldehyde was stronger than that of 4-vinylbenzoic acid, and the IC50 values were estimated as 23 mu M and 0.33 mM, respectively. Kinetic analyses showed that inhibition by both compounds was reversible and their mechanisms were mixed-II type; their inhibition constants were also determined and compared.
Citation
J Enzyme Inhib Med Chem. 2005 Jun;20(3):239-43.
URI
http://dx.doi.org/doi:10.1016/0921-5093(94)09633-8
https://dspace.xmu.edu.cn/handle/2288/10805

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