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dc.contributor.authorShi, MX
dc.contributor.authorCai, QF
dc.contributor.authorYao, LM
dc.contributor.authorMao, YB
dc.contributor.authorMing, YL
dc.contributor.authorOuyang, GL
dc.contributor.author欧阳高亮
dc.date.accessioned2011-09-16T08:48:08Z
dc.date.available2011-09-16T08:48:08Z
dc.date.issued2006
dc.identifier.citationCell Biology International,Volume 30, Issue 3, March 2006, Pages 221-226zh_CN
dc.identifier.issn1065-6995
dc.identifier.issnhttp://dx.doi.org/doi:10.1016/j.cellbi.2005.10.024
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10751
dc.description.abstractCurcumin. an active ingredient from the rhizome of the plant, Curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. It has recently been demonstrated that the chemopreventive activities of curcumin might be due to its ability to inhibit cell growth and induce apoptosis. In the present study, we have investigated the effects of curcumin on growth and apoptosis in the human ovarian cancer cell line Ho-8910 by MTT assay, fluorescence microscopy, flow cytometry and Western blotting. Our data revealed that curcumin could significantly inhibit the growth and induce apoptosis in Ho-8910 cells. A decrease in expression of Bcl-2, Bcl-X-L and pro-caspase-3 was observed after exposure to 40 mu M curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells. These activities may contribute to the anticarcingenic action of curcumin. (C) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTDzh_CN
dc.subjectcurcuminzh_CN
dc.subjectapoptosiszh_CN
dc.subjectchemopreventionzh_CN
dc.subjectovarian cancerzh_CN
dc.subjectHo-8910 cellszh_CN
dc.titleAntiproliferation and apoptosis induced by curcumin in human ovarian cancer cellszh_CN
dc.typeArticlezh_CN


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