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dc.contributor.authorSong, KK
dc.contributor.authorHuang, H
dc.contributor.authorHan, P
dc.contributor.authorZhang, CL
dc.contributor.authorShi, Y
dc.contributor.author石艳
dc.contributor.authorChen, QX
dc.contributor.author陈清西
dc.date.accessioned2011-09-16T07:51:51Z
dc.date.available2011-09-16T07:51:51Z
dc.date.issued2006
dc.identifier.citationBiochemical and Biophysical Research Communications,Volume 342, Issue 4, 21 April 2006, Pages 1147-1151zh_CN
dc.identifier.issn0006-291X
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.bbrc.2005.12.229
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10747
dc.description.abstractThe effects of cis- and trans-isomers of 3,5-dihydroxystilbene on the activity of mushroom tyrosinase have been studied. The results show that both cis- and trans-isomers of 3,5-diliydroxystilbetic can inhibit the diphenolase activity of the enzyme and the inhibition type was reversible. The IC50 values were estimated as 0.405 +/- 0.013 and 0.705 +/- 0.017 mM, respectively. Kinetic analysis showed that the inhibition of cis-3,5-dihydroxystilbene and trans-3,5-dihydroxystilbene on the diphenolase activity of the enzyme belonged to competitive type, and the inhibition constants (K-I) were determined to be 0.232 +/- 0.015 and 0.395 +/- 0.020 mM, respectively. In this investigation, the inhibitory effects of cis-3,5-dihydroxystilbene and trans-3,5-dihydroxystilbene on the diphenolase activity of mushroom tyrosillase were compared. The inhibitory capacity of cis-isomer was stronger than that of corresponding trans-isomer. Nevertheless, the trans-3,5-dihydroxystilbene was used more frequently than its corresponding cis-form compound. This research may offer some references for designing and synthesizing sonic novel and effective tyrosinase inhibitors. Furthermore, it may improve the use of stilbenes on the field of food preservation and depigmentation. (c) 2006 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEzh_CN
dc.subjectmushroom tyrosinasezh_CN
dc.subjectdiphenolase activityzh_CN
dc.subjectcis-3,5-dihydroxystilbenezh_CN
dc.subjecttrans-3.5-dillydroxystilbenezh_CN
dc.subjectinhibitionzh_CN
dc.subjectdepigmentationzh_CN
dc.titleInhibitory effects of cis- and trans-isomers of 3,5-dihydroxystilbene on the activity of mushroom tyrosinasezh_CN
dc.typeArticlezh_CN


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