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dc.contributor.author李兆永
dc.contributor.author陈军辉
dc.contributor.author王帅
dc.contributor.author张茹潭
dc.contributor.author史倩
dc.contributor.author郑立
dc.contributor.author王小如
dc.date.accessioned2016-05-17T02:53:59Z
dc.date.available2016-05-17T02:53:59Z
dc.date.issued2014-1-15
dc.identifier.citation质谱学报,2014,(1):10-17
dc.identifier.issn1004-2997
dc.identifier.otherZPXB201401003
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/107008
dc.description.abstract利用多级质谱技术对8种常见麻痹性贝毒素(gTX1,gTX 4,gTX2,gTX 3,dCgTX2,dCgTX3,C1和C2)在电喷雾质谱负离子模式下的分析特征进行研究。结果表明:8种目标化合物在一级质谱分析过程中均易失去1个H,形成准分子离子[M-H]-峰(基峰);在二级质谱分析过程中,各化合物的母离子([MH]-)主要通过丢失-H2O和-nHCO等中性碎片,形成稳定的特征子离子峰,并且同分异构体的二级质谱图有差异,可为含硫麻痹性贝毒素的二级质谱定性、定量分析提供依据。此外,对各目标化合物二级质谱的主要碎片峰进行三级质谱分析,对产生的主要特征碎片峰进行归属,并推测裂解途径。本研究可为电喷雾质谱在负离子模式下检测含硫麻痹性贝毒素提供参考和依据。
dc.description.abstractThe MS characteristic of eight common paralytic shellfish poisoning(PSP)toxins(GTX1,GTX4,GTX2,GTX3,dcGTX2,dcGTX3,C1and C2)were investigated by electrospray ionization multi-stage mass spectrometry(ESI-MSn)in negative ion mode.The results show that the quasi-molecular ion peak[M-H]-(base peak)of each PSP toxin is detected by ESI-MS.Stability characteristic fragment ions are observed by the neutral loss of-H2 O and-NHCO for ESI-MS2 detection,and the MS2 spectra of PSP toxin isomers aredifferent,which can provide experimental basis for qualitative and quantitative determination of sulfur containing PSP toxins by ESI-MS2.ESI-MS3 detection is performed for the main characteristic fragment ions of the target toxins produced during ESI-MS2 analysis.The main MS3 characteristics of the fragment routes are also discussed.This study can help to offer the reference and basis for determination of sulfur containing PSP toxins by electrospray ionization mass spectrometry in negative ion mode.
dc.description.sponsorship国家高技术研究发展计划(863)项目(2007AA092001-10); 国家科技支撑计划项目(2013BAK12B00); 上海市科委科研计划项目(11dz1204706)资助
dc.language.isozh_CN
dc.subject麻痹性贝毒素
dc.subject电喷雾质谱
dc.subject裂解途径
dc.subjectfragmentation pathway
dc.subjectelectrospray mass spectrometry
dc.subjectparalytic shellfish poi-soning
dc.title麻痹性贝毒素电喷雾质谱负离子模式分析特征
dc.title.alternativeMS Characteristic of Paralytic Shellfish Poisoning Toxins Detected by Electrospray Ionization Mass Spectrometry in Negative Ion Mode
dc.typeArticle


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