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dc.contributor.authorFang Wang
dc.contributor.author王芳
dc.contributor.authorXiaolan Chen
dc.contributor.author陈小兰
dc.contributor.authorZengxia Zhao
dc.contributor.author赵增侠
dc.contributor.authorShaoheng Tang
dc.contributor.author汤少恒
dc.contributor.authorXiaoqing Huang
dc.contributor.author黄小青
dc.contributor.authorchenghong LIn
dc.contributor.author林程宏
dc.contributor.authorCongbo Cai
dc.contributor.author蔡聪波
dc.contributor.authorNanfeng Zheng
dc.contributor.author郑南峰
dc.date.accessioned2011-08-26T07:00:33Z
dc.date.available2011-08-26T07:00:33Z
dc.date.issued2011-05-20
dc.identifier.citationJOURNAL OF MATERIALS CHEMISTRY,2011, 21(30):11244-11252zh_CN
dc.identifier.issn0959-9428
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10692
dc.description通讯作者地址: Chen, XL (通讯作者),Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R Chinazh_CN
dc.description.abstractA synthetic method to prepare novel multifunctional core-shell-structured mesoporous silica nanoparticles for simultaneous magnetic resonance (MR) and fluorescence imaging, cell targeting and photosensitization treatment has been developed. Superparamagnetic magnetite nanoparticles and fluorescent dyes are co-encapsulated inside nonporous silica nanoparticles as the core to provide dual-imaging capabilities (MR and optical). The photosensitizer molecules, tetra-substituted carboxyl aluminum phthalocyanine (AlC(4)Pc), are covalently linked to the mesoporous silica shell and exhibit excellent photo-oxidation efficiency. The surface modification of the core-shell silica nanoparticles with folic acid enhances the delivery of photosensitizers to the targeting cancer cells that overexpress the folate receptor, and thereby decreases their toxicity to the surrounding normal tissues. These unique advantages make the prepared multifunctional core-shell silica nanoparticles promising for cancer diagnosis and therapy.zh_CN
dc.description.sponsorshipNSFC21021061,20925103,20871100,Fok Ying Tung Education Foundation 121011 NSF of Fujian Province 2009J06005 Fundamental Research Funds for the Central Universities 2010121015 Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministryzh_CN
dc.language.isoen_USzh_CN
dc.publisherROYAL SOC CHEMISTRYzh_CN
dc.subjectDRUG-DELIVERYzh_CN
dc.subjectPHOTOSENSITIZING AGENTSzh_CN
dc.subjectSILICA NANOPARTICLESzh_CN
dc.subjectANTICANCER DRUGSzh_CN
dc.subjectCANCERzh_CN
dc.subjectEXCITATIONzh_CN
dc.subjectCARRIERSzh_CN
dc.subjectVECTORSzh_CN
dc.subjectSYSTEMzh_CN
dc.subjectOXYGENzh_CN
dc.titleSynthesis of magnetic, fluorescent and mesoporous core-shell-structured nanoparticles for imaging, targeting and photodynamic therapyzh_CN
dc.typeArticlezh_CN


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