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Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus hisporus) tyrosinase

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Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus hisporus) tyrosinase.htm (413bytes)
Date
2007
Author
Wang, Qin
王勤
Qiu, Ling
Chen, Xiang-ren
Song, Kang-Kang
Shi, Yan
石艳
Chen, Qing-Xi
陈清西
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  • 生命科学-已发表论文 [5901]
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Abstract
The inhibitory effects of phloridzin dihydrate on the activity of mushroom tyrosinase have been studied. The results show that phloridzin can inhibit the diphenolase activity of the enzyme and the inhibition displays to be reversible. The IC50 value was estimated as 110 mu M. The kinetic analysis showed that the inhibition of phloridzin on the diphenolase activity of the enzyme is of competitive type, and the inhibition constant (K-I) was determined to be 64.3 mu M. The inhibitory effects of the different concentrations of phloridzin on the monophenolase activity were also studied. There were almost no changes in the lag period and the steady-state rate, while the plateaus in the inhibitory curve lowered with increasing the concentration of phloridzin when using tyrosine as a substrate. (c) 2006 Published by Elsevier Ltd.
Citation
Bioorg Med Chem. 2007 Feb 1;15(3):1568-71
URI
http://dx.doi.org/doi:10.1016/j.bmc.2005.11.048
https://dspace.xmu.edu.cn/handle/2288/10685

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