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dc.contributor.authorLi, Guang
dc.contributor.authorShi, Peng(Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA)
dc.contributor.authorWang, Yiquan
dc.contributor.author王义权
dc.date.accessioned2011-08-25T13:46:32Z
dc.date.available2011-08-25T13:46:32Z
dc.date.issued2007
dc.identifier.citationGenomics (2007) 89: 385-91zh_CN
dc.identifier.issn0888-7543
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.ygeno.2006.07.015
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10670
dc.description.abstractABCA is a subfamily of ATP-binding-cassette (ABC) transporter genes. In this subfamily, it was found that five ABCA genes cluster in a head-to-tail pattern in the human and mouse genomes, but only one was found in fish. To understand better the evolution of this cluster of genes, we screened 11 vertebrate genome sequences and newly identified 28 ABCA cluster genes. Comparative genomic analysis reveals that the ABCA5 gene is relatively evolutionarily conserved. In contrast, the repertoires of the other ABCA genes in this cluster diverge tremendously among species, which is due mainly to postspeciation duplications. In addition, maximum likelihood analysis reveals that positive selection is acting on the paralogous genes ABCA6 and Abca8a, Suggesting that these two genes have possibly acquired new functions after duplication. Because most eukaryotic ABC proteins integrate into the cytoplasmic membrane and transport a wide range Of Substrates across it, we conjecture that newly duplicated ABCA cluster genes are under diversifying selection for the ability to recognize a diverse array of substrates. (c) 2006 Elsevier Inc. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEzh_CN
dc.subjectgene familyzh_CN
dc.subjectABCA chromosome 17q24 clusterzh_CN
dc.subjectpositive selectionzh_CN
dc.subjectgene duplicationzh_CN
dc.subjectevolutionzh_CN
dc.titleEvolutionary dynamics of the ABCA chromosome 17q24 cluster genes in vertebrateszh_CN
dc.typeArticlezh_CN


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