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dc.contributor.authorYu, Chundong
dc.contributor.author俞春东
dc.contributor.authorYork, Brian(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston)
dc.contributor.authorWang, Shu(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston)
dc.contributor.authorFeng, Qin(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston)
dc.contributor.authorXu, Jianming(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston)
dc.contributor.authorO'Malley, Bert W.(Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston)
dc.date.accessioned2011-08-25T13:24:30Z
dc.date.available2011-08-25T13:24:30Z
dc.date.issued2007
dc.identifier.citationMOLECULAR CELL,Volume 25, Issue 5, 9 March 2007, Pages 765-778zh_CN
dc.identifier.issn1097-2765
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.molcel.2007.01.025
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10667
dc.description.abstractSteroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator for nuclear receptors and other transcription factors. Although multiple physiological roles of SRC-3 have been revealed, its involvement in the inflammatory process remains unclear. Herein we show that SRC-3(-/-) mice are markedly hypersensitive to LPS-induced endotoxic shock. In response to LIPS, SRC-3(-/-) macrophages produce significantly more proinflammatory cytokines such as TNF-alpha, IL-6, and IL-1 beta than wild-type controls, although they express similar amounts of cytokine mRNAs, suggesting that SRC-3 can exert effects at translational levels. Increased heavy polysome-associated TNF-alpha and IL-10 mRNAs in SRC-3(-/-) macrophages implicate SRC-3 as a translational repressor. SRC-3 may cooperate with other translational repressors such as TIA-1 and TIAR to regulate cytokine mRNA translation. Collectively, our studies reveal an essential function of SRC-3 as a coordinator of inflammatory mRNA translation and as a physiologic protective factor against the lethal endotoxic shock triggered by an acute inflammatory response.zh_CN
dc.language.isoenzh_CN
dc.publisherCELL PRESSzh_CN
dc.titleAn essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory responsezh_CN
dc.typeArticlezh_CN


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