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dc.contributor.authorTaechowisan, Thongchai(Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand)
dc.contributor.authorTuntiwachwuttikul, Pittaya(Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand)
dc.contributor.authorLu, Chunhua
dc.contributor.author鲁春华
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.contributor.authorLumyong, Saisamorn(Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand)
dc.contributor.authorTaylor, Walter C.(School of Chemistry, University of Sydney, NSW, Australia)
dc.date.accessioned2011-08-25T13:09:44Z
dc.date.available2011-08-25T13:09:44Z
dc.date.issued2007
dc.identifier.citationImmunol Invest.2007, Vol. 36, No. 2 , Pages 203-211zh_CN
dc.identifier.issn0882-0139
dc.identifier.urihttp://dx.doi.org/doi:10.1080/08820130600992115
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10665
dc.description.abstractThis research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE(2), and TNF-alpha and also on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar effect was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The inhibitory effects were shown in concentration-dependent manners. The 5,7,4'-Trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha.zh_CN
dc.language.isoenzh_CN
dc.publisherTAYLOR & FRANCIS INCzh_CN
dc.subject4-arylcoumarinszh_CN
dc.subjectanti-inflammatory activityzh_CN
dc.subjectendophytic Streptomyceszh_CN
dc.subjectmurine macrophage RAW 264.7 cellszh_CN
dc.titleAnti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)zh_CN
dc.typeArticlezh_CN


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