• 中文
    • English
  • English 
    • 中文
    • English
  • Login
View Item 
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)

Thumbnail
Full Text
Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009).htm (409bytes)
Date
2007
Author
Taechowisan, Thongchai(Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand)
Tuntiwachwuttikul, Pittaya(Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn, Pathom, Thailand)
Lu, Chunhua
鲁春华
Shen, Yuemao
沈月毛
Lumyong, Saisamorn(Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand)
Taylor, Walter C.(School of Chemistry, University of Sydney, NSW, Australia)
Collections
  • 生命科学-已发表论文 [5901]
Show full item record
Abstract
This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE(2), and TNF-alpha and also on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar effect was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The inhibitory effects were shown in concentration-dependent manners. The 5,7,4'-Trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha.
Citation
Immunol Invest.2007, Vol. 36, No. 2 , Pages 203-211
URI
http://dx.doi.org/doi:10.1080/08820130600992115
https://dspace.xmu.edu.cn/handle/2288/10665

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies