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dc.contributor.author曾荣今
dc.contributor.author周再春
dc.contributor.author汪朝旭
dc.contributor.author李筱芳
dc.contributor.author陈忠
dc.contributor.author于贤勇
dc.date.accessioned2016-05-17T02:51:19Z
dc.date.available2016-05-17T02:51:19Z
dc.date.issued2009
dc.identifier.citation有机化学,2009,(3):173-178
dc.identifier.issn0253-2786
dc.identifier.otherYJHU200903025
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/106274
dc.description.abstract5-乙氧羰基-4-芳基-6-甲基-3,4-二氢嘧啶-2-酮与丁炔二酸二甲酯反应,合成了系列新的噻唑并[3,2-A]嘧啶类化合物,反应具有时间短、收率高、后处理简单等优点.采用nMr(1H,13C,COSy,HSQC和HMbC),Ir等多种谱学技术,结合元素分析对产物进行详细表征,通过对目标产物的1,3-偶极环加成的衍生化产物进行X射线单晶衍射而确定目标产物的结构.
dc.description.abstractA new class of thiazolo[3,2-a]pyrimidine compounds were synthesized by the reaction of 5-carbethoxyl-4-aryl-6-methyl-1,2,3,4-tetrahydropyrimidin-2-ones with dimethyl acetylenedicarboxylate.The reaction has the advantages of excellent yields and simple workup procedures.The products were char-acterized thoroughly by IR and NMR(1H,13C,COSY,HSQC and HMBC) together with elemental analysis.The X-ray crystallographic analysis of the 1,3-dipolar cycloaddition derivative of the title product provided the direct information for the structure of the product.
dc.description.sponsorship国家自然科学基金(Nos.20772027;20803020);中国博士后科学基金(No.20070410805);卫生部科学研究基金-福建省卫生教育联合攻关计划(No.WKJ2008-2-036);厦门市重大疾病攻关研究基金(No.3502Z20051027);湖南科技大学博士基金(No.E50839)资助项目
dc.language.isozh_CN
dc.subject噻唑并[3
dc.subject2-a]嘧啶
dc.subject丁炔二酸二甲酯
dc.subject环加成
dc.subject晶体结构
dc.subjectthiazolo[3
dc.subject2-a]pyrimidine
dc.subjectdimethyl acetylenedicarboxylate
dc.subjectcycloaddition
dc.subjectcrystal structure
dc.title新型噻唑并[3,2-a]嘧啶类化合物的合成
dc.title.alternativeSynthesis of Novel Thiazolo[3,2-a]pyrimidine Compounds
dc.typeArticle


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