硫酸氨基葡萄糖喷雾干燥后稳定性试验

Abstract

目的硫酸氨基葡萄糖喷雾干燥后稳定性试验。方法采用喷雾干燥法制得微囊化硫酸氨基葡萄糖,以产品得率、流动性、玻璃转化温度和贮藏稳定性为指标,考察不同配料的不同添加量对产品稳定性的影响。结果分别添加0.5%、1.0%、2.0%、3.0%和5.0%的环糊精、明胶、共聚维酮能有效地改善硫酸氨基葡萄糖的喷雾干燥粉末得率、粉末流动性,提高产品的贮藏稳定性和玻璃化转变温度结论环糊精、明胶、共聚维酮能有效提高硫酸氨基葡萄糖的稳定性。

Objective To study the stability of glucosamine sulfate prepared by spray drying.Methods The microcapsules of glucosamine sulfate were produced by spray drying,and the effects of different adjuvants on the indices of the microcapsules,such as the yield,fluidity,glass transition temperature and store stability were compared.Results and conclusion The yield,fluidity,glass transition temperature and stability of glucosamine sulfate could be greatly improved by adding 0.5%,1.0%,2.0%,3.0% and 5.0% cyclodextrin,gelatin and copvidone.