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dc.contributor.author李忌
dc.contributor.author郑耘
dc.contributor.author郑荣梁
dc.contributor.author刘自民
dc.contributor.author贾忠健
dc.date.accessioned2016-05-17T02:51:03Z
dc.date.available2016-05-17T02:51:03Z
dc.date.issued1995
dc.identifier.citation中国药学杂志,1995,(5):269-271
dc.identifier.issn1001-2494
dc.identifier.otherZGYX505.007
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/106206
dc.description.abstract采用抗癌药筛选新方法-MTT法,研究了6种从中草药马先蒿(PEdICulArIS)中分离提取的苯丙素甙化合物(PHEnylPrOPAnOIdglyCOSIdES,PPg)对3种不同组织癌细胞生长的抑制活性。结果表明:6种PPg的抗肿瘤活性强度与其化学结构密切相关;它们的抑癌活性强度顺序为:ISOVErbASCOSIdE,VErbASCOSIdE,ECHInACOSIdE,PEdICulArIOSIdEA>CISTAnOSIdEd>PErMETHylVErbASCOSIdE;即分子中酚羟基越多,抗肿瘤活性愈强,当酚羟基完全被甲基化后,则对癌细胞生长无抑制作用。
dc.description.abstractUsing the MTT colorimetric assay,we studied antitumour eFFects of 6 phenyl-propanoid glycosides(PPG) From Pedicularis on three diFFerent tumour cell lines, The antitumoureFFects of 6 PPG were related to their chemical structure,Their antitumour eFFects ranked asisoverbascoside, verbascoside,echinacoside, pedicularioside A >cistanoside D>permethyl verbas-coside.It was shown that the more number of phenolic hydroxyl groups,the stronger PPG’s anti-tumour eFFects.The phenolic hydroxyl groups were methoxylated,and PPG couldn’t inhibit thegrowth of tumour cells.
dc.description.sponsorship国家自然科学基金及福建省自然科学基金
dc.language.isozh_CN
dc.subject苯丙素成(PPG)
dc.subjectMTT
dc.subject肝癌SMMC-7721
dc.subject肺腺癌L_(342)
dc.subject胃腺癌MGc-803
dc.subjectphenylpropanoid glycosides (PPG)
dc.subjectMTT
dc.title苯丙素甙化合物的抗肿瘤活性
dc.title.alternativeAntitumour eFFects of phenylpropanoid glycosides
dc.typeArticle


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