苯丙素甙化合物的抗肿瘤活性

Abstract

采用抗癌药筛选新方法-MTT法，研究了6种从中草药马先蒿（PEdICulArIS）中分离提取的苯丙素甙化合物（PHEnylPrOPAnOIdglyCOSIdES，PPg）对3种不同组织癌细胞生长的抑制活性。结果表明：6种PPg的抗肿瘤活性强度与其化学结构密切相关；它们的抑癌活性强度顺序为：ISOVErbASCOSIdE，VErbASCOSIdE，ECHInACOSIdE，PEdICulArIOSIdEA＞CISTAnOSIdEd＞PErMETHylVErbASCOSIdE；即分子中酚羟基越多，抗肿瘤活性愈强，当酚羟基完全被甲基化后，则对癌细胞生长无抑制作用。

Using the MTT colorimetric assay,we studied antitumour eFFects of 6 phenyl-propanoid glycosides(PPG) From Pedicularis on three diFFerent tumour cell lines, The antitumoureFFects of 6 PPG were related to their chemical structure,Their antitumour eFFects ranked asisoverbascoside, verbascoside,echinacoside, pedicularioside A >cistanoside D>permethyl verbas-coside.It was shown that the more number of phenolic hydroxyl groups,the stronger PPG’s anti-tumour eFFects.The phenolic hydroxyl groups were methoxylated,and PPG couldn’t inhibit thegrowth of tumour cells.