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dc.contributor.authorWu, Ting
dc.contributor.authorWu, Xiao-lu
dc.contributor.authorOu, Shan-hai
dc.contributor.authorLin, Chun-xin
dc.contributor.authorCheng, Tong
dc.contributor.authorLi, Shao-wei
dc.contributor.authorNg, Mun Hon
dc.contributor.authorZhang, Jun
dc.contributor.author张军
dc.contributor.authorXia, Ning-shao
dc.contributor.author夏宁邵
dc.date.accessioned2011-08-22T14:01:33Z
dc.date.available2011-08-22T14:01:33Z
dc.date.issued2007
dc.identifier.citationMolecular Immunology,Volume 44, Issue 12, May 2007, Pages 3261-3266zh_CN
dc.identifier.issn0161-5890
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.molimm.2007.01.002
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10541
dc.description.abstractThe candidate particulate hepatitis E vaccine, HEV 239, has been shown to be an efficacious vaccine in primates, and clinical study to date shows it to be safe and irnmunogenic for humans. The antigenicity of HEV 239 is virtually identical to its N-terminal 26 amino acids truncated protein, E2, which is not particulate but soluble. However, 14EV 239 is over 200 times more immunogenic than E2. In present study, several events underlying this dramatic immunogenicity difference have been addressed. (1) HEV 239 can efficiently evoke a vigorous and predominant T cell response while E2 cannot induce detectable T cell response; (2) the dominant T cell epitopes in HEV 239 are identified, and both are also contained integrally in E2; (3) priming mice with Th epitope peptide, can partially rescue the weak immunogenicity of E2 in alum adjuvant and (4) HEV 239 but not E2 can induce significant antibody response in athymic mice, which indicates that HEV 239 can directly activate B cell more efficiently. These results contribute to a better understanding of the mechanisms involved in the significant high immunogenicity of particulate antigen and may provide knowledge for the rational design and development of future vaccines. (c) 2007 Published by Elsevier Ltd.zh_CN
dc.language.isoenzh_CN
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDzh_CN
dc.subjecthepatitis E viruszh_CN
dc.subjectparticulatezh_CN
dc.subjectvaccinezh_CN
dc.subjectimmunogenicityzh_CN
dc.titleDifference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicityzh_CN
dc.typeArticlezh_CN


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