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Difference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicity

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Difference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicity.htm (413bytes)
Date
2007
Author
Wu, Ting
Wu, Xiao-lu
Ou, Shan-hai
Lin, Chun-xin
Cheng, Tong
Li, Shao-wei
Ng, Mun Hon
Zhang, Jun
张军
Xia, Ning-shao
夏宁邵
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  • 生命科学-已发表论文 [5901]
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Abstract
The candidate particulate hepatitis E vaccine, HEV 239, has been shown to be an efficacious vaccine in primates, and clinical study to date shows it to be safe and irnmunogenic for humans. The antigenicity of HEV 239 is virtually identical to its N-terminal 26 amino acids truncated protein, E2, which is not particulate but soluble. However, 14EV 239 is over 200 times more immunogenic than E2. In present study, several events underlying this dramatic immunogenicity difference have been addressed. (1) HEV 239 can efficiently evoke a vigorous and predominant T cell response while E2 cannot induce detectable T cell response; (2) the dominant T cell epitopes in HEV 239 are identified, and both are also contained integrally in E2; (3) priming mice with Th epitope peptide, can partially rescue the weak immunogenicity of E2 in alum adjuvant and (4) HEV 239 but not E2 can induce significant antibody response in athymic mice, which indicates that HEV 239 can directly activate B cell more efficiently. These results contribute to a better understanding of the mechanisms involved in the significant high immunogenicity of particulate antigen and may provide knowledge for the rational design and development of future vaccines. (c) 2007 Published by Elsevier Ltd.
Citation
Molecular Immunology,Volume 44, Issue 12, May 2007, Pages 3261-3266
URI
http://dx.doi.org/doi:10.1016/j.molimm.2007.01.002
https://dspace.xmu.edu.cn/handle/2288/10541

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