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dc.contributor.authorZhang, Jiliang
dc.contributor.authorZuo, Zhenghong
dc.contributor.author左正宏
dc.contributor.authorChen, Yixin
dc.contributor.author陈奕欣
dc.contributor.authorZhao, Yang
dc.contributor.authorHu, Shuai
dc.contributor.authorWang, Chonggang
dc.contributor.author王重刚
dc.date.accessioned2011-08-22T13:46:08Z
dc.date.available2011-08-22T13:46:08Z
dc.date.issued2007
dc.identifier.citationAquatic Toxicology,Volume 83, Issue 3, 20 July 2007, Pages 174-179zh_CN
dc.identifier.issn0166-445X
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.aquatox.2007.03.018
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10538
dc.description.abstractOrganotin compounds, such as tributyltin (TBT) used as an antifouling biocide, can induce masculinization in female mollusks. However, few studies addressing the effect of TBT in fish have been reported. This study was conducted to investigate effects of TBT at environmental levels (1, 10, 100 ng/L) on the development of ovary in female cuvier. TBT exposure elevated testosterone levels, increased the ratio of testosterone to 17 beta-estradiol and decreased 17 beta-estradiol levels in ovaries after 50 days compared to the control. Three stages of follicles (primary growth stage, yolk vesicle stage, vitellogenic stage) were observed in the ovaries of cuvier at the control and 1 ng/L TBT group. The ovaries at the 10 ng/L TBT group were characterized by the lack of vitellogenic stage follicles and instead had higher proportions of primary growth stage follicles. 100 ng/L TBT resulted in follicles that were entirely at the earliest (primary growth stage) stages of development. There was a significant increase in apoptotic ovarian follicular cells judged by TUNEL-positive cell at the 10 ng/L TBT group. The TUNEL-positive follicles were observed at the 100 ng/L TBT group. The result in the present study showed that TBT at environmentally realistic concentrations can inhibit the ovarian development in fish. Besides the changes of sex hormone induced by TBT, apoptosis appears to be one mechanism affecting ovarian development. (c) 2007 Published by Elsevier B.V.zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjecttributyltinzh_CN
dc.subjecttestosteronezh_CN
dc.subject17 beta-estradiolzh_CN
dc.subjectapoptosiszh_CN
dc.titleEffect of tributyltin on the development of ovary in female cuvier (Sebastiscus marmoratus)zh_CN
dc.typeArticlezh_CN


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