A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida
Xu, Zhen（Tsinghua University）
Xiong, Bo（Tsinghua University）
Cao, Ying（Tsinghua University）
Zhang, Min（Tsinghua University）
Chan, Siu-Chiu（Department of Biochemistry, Hong Kong University of Science and Technology）
Zhou, Hai-Meng（Tsinghua University）
Meng, Anming（Tsinghua University）
- 生命科学－已发表论文 
Axin is a scaffold protein that controls multiple important pathways, including the canonical Wnt pathway and JNK signaling. Here we have identified an Axin-interacting protein, Aida, which blocks Axin-mediated JNK activation by disrupting Axin homodimerization. During investigation of in vivo functions of Axin/JNK signaling and aida in development, it was found that Axin, besides ventralizing activity by facilitating P-catenin degradation, possesses adorsalizing activity that is mediated by Axin-induced JNK activation. This dorsalizing activity is repressed when aida is overexpressed in zebrafish embryos. Whereas Aida-MO injection leads to dorsalized embryos, JNK-MO and MKK4-MO can ventralize embryos. The anti-dorsalization activity of aida is conferred by its ability to block Axin-mediated JNK activity. We further demonstrate that dorsoventral patterning regulated by Axin/JNK signaling is independent of maternal or zygotic Wnt signaling. We have thus identified a dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis.
CitationDEVELOPMENTAL CELL，Volume 13, Issue 2, 7 August 2007, Pages 268-282
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