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dc.contributor.authorWu Yu-qiong
dc.contributor.authorWang Chong-gang
dc.contributor.author王重刚
dc.contributor.authorWang Yun
dc.contributor.authorZhao Yang
dc.contributor.authorChen Yi-xin
dc.contributor.author陈奕欣
dc.contributor.authorZuo Zheng-hong
dc.contributor.author左正宏
dc.date.accessioned2011-08-21T07:51:37Z
dc.date.available2011-08-21T07:51:37Z
dc.date.issued2007
dc.identifier.citationJournal of Environmental Sciences,Volume 19, Issue 9, 2007, Pages 1129-1135zh_CN
dc.identifier.issn1001-0742
dc.identifier.urihttp://dx.doi.org/doi:10.1016/S1001-0742(07)60184-3
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10511
dc.description.abstractIt has been reported that there is an interaction between Benzo[a]pyrene (BaP), a widespread carcinogenic polycyclic aromatic hydrocarbon, and tributyltin (TBT), an organometal used as an antifouling biocide. This study was therefore designed to examine the potential in vivo influence of BaP, TBT and their mixture on splenic antioxidant defense systems of Sebastiscus marmoratus. The fish were exposed to water containing environmentally relevant concentrations of BaP, TBT and their mixture. Spleens were collected for biochemical analysis after exposure for 7, 25, 50 d and after recovery for 7, 20 d. Cotreatment with BaP and TBT for 7 d potentiated the induction of glutathione peroxidase (GPx) activity by BaP or TBT alone. The cotreatment for 25 and 50 d resulted in inhibition of GPx activity, which was similar to the effect of TBT. Splenic glutathione S-transferase (GST) activities were significantly elevated in S. marmoratus exposed to BaP starting from 7 d and remained high up to 25 d. However, no further activity change was found with prolonged exposure. Cotreatment of BaP and TBT primarily inhibited the GST activity, which was similar to the effect of TBT. Cotreatment with BaP and TBT for 25 or 50 d potentiated the depletion of GSH (glutathione) by BaP or TBT alone. MDA (malondialdehyde) contents in spleen of S. marmoratus were not significantly altered compared with the control during the test period. Spleen, as an immune organ, is sensitive to exposure of BaP or TBT. It should have an effective mechanism to counteract oxidative damage. Antioxidative defense systems in spleen of S. marmoratus should be considered as potential biomarkers. Short-term exposure of BaP or TBT could result in induction of antioxidant defense system. A significant decrease of these indices, such as GSH, GST, GPx might indicate more severe contamination.zh_CN
dc.language.isoenzh_CN
dc.publisherSCIENCE CHINA PRESSzh_CN
dc.subjecttributyltinzh_CN
dc.subjectbenzo[a]pyrenezh_CN
dc.subjectantioxidant defensezh_CN
dc.subjectcombined effectzh_CN
dc.subjectSebastiscus marmoratuszh_CN
dc.titleAntioxidant responses to benzo[a]pyrene, tributyltin and their mixture in the spleen of Sebasticus marmoratuszh_CN
dc.typeArticlezh_CN


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