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dc.contributor.authorLiang, Jie
dc.contributor.authorKe, Guifen
dc.contributor.authorYou, Wenjun( No 1 Hosp Xiamen)
dc.contributor.authorPeng, Zi
dc.contributor.authorLan, Jie(McGill Univ, Montreal Childrens Hosp)
dc.contributor.authorKalesse, Markus(Leibniz Univ Hannover, Inst Organ Chem)
dc.contributor.authorTartakoff, Alan M.(Case Western Reserve Univ, Dept Pathol, Cell Biol Program, Cleveland, OH USA)
dc.contributor.authorKaplan, Feige(McGill Univ, Montreal Childrens Hosp)
dc.contributor.authorTao, Tao
dc.contributor.author陶涛
dc.date.accessioned2011-08-20T10:19:50Z
dc.date.available2011-08-20T10:19:50Z
dc.date.issued2007
dc.identifier.citationMolecular and Cellular Biochemistry ,Volume 307, Numbers 1-2, 93-100zh_CN
dc.identifier.issn0300-8177
dc.identifier.urihttp://dx.doi.org/doi:10.1007/s11010-007-9588-1
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10486
dc.description.abstractImportin 13 is a member of the importin beta superfamily of nuclear transport proteins and is expressed in multiple tissues at high levels both in humans and rodents, including fetal lung, brain, and heart. In order to elucidate potential functions of imp13 in the heart, we have used rat imp13 as bait to screen a human heart cDNA library and identified an interaction with the C-terminal peptide of myopodin (a.a. 360-698), an actin-bundling protein, associated with tumor-suppressor activity that localizes to both the cytoplasm and the nucleus. We have used GST-pull down assays and co-immunoprecipitation experiments to demonstrate an interaction between imp13 and full-length myopodin and observed that RanGTP dissociates the myopodin-imp13 complex. In studies of cultured cells, we show that both imp13 siRNA and a C-terminal fragment of imp13 protein prevent nuclear localization of myopodin. We, therefore, conclude that imp13 functions in myopodin import and we suggest that the regulation of these events is critical for normal and abnormal cellular differentiation.zh_CN
dc.language.isoenzh_CN
dc.publisherSPRINGERzh_CN
dc.subjectimportin 13zh_CN
dc.subjectmyopodinzh_CN
dc.subjectinteractionzh_CN
dc.subjectnuclear importzh_CN
dc.titleInteraction between importin 13 and myopodin suggests a nuclear import pathway for myopodinzh_CN
dc.typeArticlezh_CN


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