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dc.contributor.authorLi, Guang
dc.contributor.authorZhang, Qiu-Jin
dc.contributor.authorJi, Zhi-Liang
dc.contributor.author纪志梁
dc.contributor.authorWang, Yi-Quan
dc.contributor.author王义权
dc.date.accessioned2011-08-20T10:04:29Z
dc.date.available2011-08-20T10:04:29Z
dc.date.issued2007
dc.identifier.citationGene,Volume 405, Issues 1-2, 15 December 2007, Pages 88-95zh_CN
dc.identifier.issn0378-1119
dc.identifier.urihttp://dx.doi.org/doi:10.1016/j.gene.2007.09.018
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10484
dc.description.abstractPrevious studies showed that the vertebrate ABCA subfamily, one subgroup of the ATP-binding-cassette superfamily, has evolved rapidly in terms of gene duplication and loss. To further uncover the evolutionary history of the ABCA subfamily, we characterized ABCA members of two amphioxus species (Branchiostoma floridae and B. belcheri), the closest living invertebrate relative to vertebrates. Phylogenetic analysis indicated that these two species have the same set of ABCA genes (both containing six members). Five of these genes have clear orthologs in vertebrate, including one cephalochordate-specific duplication and one vertebrate-specific duplication. In addition, it is found that human orthologs of amphioxus ABCA1/4/7 and its neighboring genes mainly localize on chromosome 1, 9, 19 and 5. Considering that most of analyzed amphioxus genes have clear orthologs in zebrafish, we conclude these four human paralogous regions might derive from a common ancestral region by genome duplication occurred prior to teleost/tetrapod split. Therefore, the present results provide new evidence for 2R hypothesis. (c) 2007 Elsevier B.V. All rights reserved.zh_CN
dc.language.isoenzh_CN
dc.publisherELSEVIER SCIENCE BVzh_CN
dc.subjectamphioxuszh_CN
dc.subjectorthologzh_CN
dc.subjecthomologzh_CN
dc.subjectcomparative genomicszh_CN
dc.subjectgenome duplicationzh_CN
dc.titleOrigin and evolution of vertebrate ABCA genes: A story from amphioxuszh_CN
dc.typeArticlezh_CN


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