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dc.contributor.author陈晖
dc.contributor.author方华
dc.contributor.author张怡评
dc.contributor.author陈伟珠
dc.contributor.author洪专
dc.contributor.author易瑞灶
dc.date.accessioned2016-05-17T02:29:09Z
dc.date.available2016-05-17T02:29:09Z
dc.date.issued2015-1-20
dc.identifier.citation化学分析计量,2015,(1):8-11
dc.identifier.issn1008-6145
dc.identifier.otherHXFJ201501003
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/104817
dc.description.abstract研制了海藻糖国家标准样品。以食品级海藻糖粗品为原料,纯化制备海藻糖,采用红外光谱(Ir)、质谱和核磁共振谱(nMr)以及单晶衍射等方法进行结构确证。样品分装成400瓶后,采用离子色谱法进行均匀性、稳定性检验和定值分析。从样品中随机抽取15瓶进行均匀性检验,经f检验表明,在95%的置信区间范围内,样品均匀性良好。在40℃下,经过24个月稳定性考察,结果表明样品稳定性良好。标准样品经国内8家具有分析资质的实验室进行协同定值,并评定了定值结果的不确定度,海藻糖标准样品定值结果为99.72%,扩展不确定度为0.26%(k=1.96)。该标准样品达到国家标准样品的技术要求,可用于有关海藻糖的方法校正和质量控制。
dc.description.abstractTrehalose certified reference material was developed.Trehalose was purified from the crude product.The structure of trehalose certified reference material was comfirmed by infrared spectroscopy(IR),mass spectrometry,NRM and XRD.Trehalose was divided into 400 bottles.The homogeneity and stability testing and quantitative analysis were evaluated by ion chromatography method.According to analysis procedure of homogeneity,15 bottles of sample were randomly taken from 400 bottles,and the results were validated by F-test statistical methods.The stability inspection was carried on the long-term(24 months),and the results indicated that the period for trehalose storage was 24 months at 40 ℃.A cooperative certification was conducted by 8 qualified laboratories.The certified purity value of the reference material of trehalose was 99.72%with relative expaned uncertainty of 0.26%(k=1.96).The reference material can conform to the technical requirement of the certified reference material,and it can be used for validation and quality control regarding trehalose.
dc.description.sponsorship福建省科技计划项目(2013N01010205); 厦门市海洋经济创新发展区域示范项目(12PZP001SF10); 海洋公益行业科研专项(201005020–1); 厦门市科技计划项目(3502Z20122009)
dc.language.isozh_CN
dc.subject海藻糖
dc.subject标准样品
dc.subject离子色谱法
dc.subject定值
dc.subject不确定度
dc.subjecttrehalose
dc.subjectcertified reference material
dc.subjection chromatography
dc.subjectcertification
dc.subjectuncertainty
dc.title海藻糖标准样品的研制
dc.title.alternativeDevelopment of Trehalose Certified Reference Material
dc.typeArticle


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