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dc.contributor.authorTaechowisan, Thongchai(Silpakorn Univ)
dc.contributor.authorLu, Chunhua
dc.contributor.author鲁春华
dc.contributor.authorShen, Yuemao
dc.contributor.author沈月毛
dc.contributor.authorLumyong, Saisamorn(Chiang Mai Univ)
dc.date.accessioned2011-08-20T08:30:42Z
dc.date.available2011-08-20T08:30:42Z
dc.date.issued2008
dc.identifier.citationFood and Agricultural Immunology, Volume 18, Numbers 3-4, September 2007 , pp. 203-211(9)zh_CN
dc.identifier.issn0954-0105
dc.identifier.urihttp://dx.doi.org/doi:10.1080/09540100701788636
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/10467
dc.description.abstractThis study was undertaken to investigate the effect of 4-arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as a pretreatment at concentrations ranging from 0.001 to 1 g/kg, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.zh_CN
dc.language.isoenzh_CN
dc.publisherTAYLOR & FRANCIS LTDzh_CN
dc.subject4-arylcoumarinszh_CN
dc.subjectimmediate-type allergic reactionzh_CN
dc.subjectmast cellszh_CN
dc.subjecttumor necrosis factor-alphazh_CN
dc.subjectinterleukin-6zh_CN
dc.title4-arylcoumarin inhibits immediate-type allergyzh_CN
dc.typeArticlezh_CN


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