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4-arylcoumarin inhibits immediate-type allergy

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A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.htm (444bytes)
Date
2008
Author
Taechowisan, Thongchai(Silpakorn Univ)
Lu, Chunhua
鲁春华
Shen, Yuemao
沈月毛
Lumyong, Saisamorn(Chiang Mai Univ)
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  • 生命科学-已发表论文 [5901]
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Abstract
This study was undertaken to investigate the effect of 4-arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as a pretreatment at concentrations ranging from 0.001 to 1 g/kg, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
Citation
Food and Agricultural Immunology, Volume 18, Numbers 3-4, September 2007 , pp. 203-211(9)
URI
http://dx.doi.org/doi:10.1080/09540100701788636
https://dspace.xmu.edu.cn/handle/2288/10467

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