• 中文
    • English
  • English 
    • 中文
    • English
  • Login
View Item 
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
  •   DSpace Home
  • 生命科学学院
  • 生命科学-已发表论文
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Subunit-subunit interactions in the human 26S proteasome

Thumbnail
Full Text
A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.htm (413bytes)
Date
2008
Author
Chen, Chuan
Huang, Caoxin
Lin, Wenbo
Ke, Guifen
Zhang, Hongxin
Tao, Tao
陶涛
Chen, Shouhui(Zhongshan Hosp Xiamen)
Wang, Bing(Med Sch Xiamen)
Huang, Jian(Natl Ctr Genom)
Han, Zeguang(Natl Ctr Genom)
Ma, Lixin(Hubei Univ)
Huo, Keke(Fudan Univ)
Yang, Pengyuan(Fudan Univ)
He, Fuchu( Beijing Proteom Ctr)
Collections
  • 生命科学-已发表论文 [5901]
Show full item record
Abstract
Ubiquitin-dependent proteolysis is mediated by the proteasome. To understand the structure and function of the human 26S proteasome, we cloned complete ORFs of 32 human proteasome subunits and conducted a yeast two-hybrid analysis of their interactions with each other. We observed that there are 114 interacting-pairs in the human 26S proteasome. About 10% (11/114) of these interacting-pairs was confirmed by the GST-pull down analysis. Among these observed interacting subunits, 58% (66/114) are novel and the rest 42% (48/114) has been reported previously in human or in other species. We observed new interactions between the 19S regulatory particle and the P-rings of the 20S catalytic particle and therefore proposed a modified model of the 26S proteasome.
Citation
PROTEOMICS,Vol 8 Issue 3 ,pp508-520
URI
http://dx.doi.org/doi:10.1002/pmic.200700588
https://dspace.xmu.edu.cn/handle/2288/10466

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies